Ubiquitination pathway model for the barber's pole worm – Haemonchus contortus

Y Zheng; G Ma; T Wang; A Hofmann; J Song; RB Gasser; ND Young

Journal article

Ubiquitination pathway model for the barber's pole worm – Haemonchus contortus

Y Zheng, G Ma, T Wang, A Hofmann, J Song, RB Gasser, ND Young

International Journal for Parasitology | Published : 2022

DOI: 10.1016/j.ijpara.2022.06.001

Abstract

The ubiquitin-mediated pathway has been comprehensively explored in the free-living nematode Caenorhabditis elegans, but very little is known about this pathway in parasitic nematodes. Here, we inferred the ubiquitination pathway for an economically significant and pathogenic nematode – Haemonchus contortus – using abundant resources available for C. elegans. We identified 215 genes encoding ubiquitin (Ub; n = 3 genes), ubiquitin-activating enzyme (E1; one), -conjugating enzymes (E2s; 21), ligases (E3s; 157) and deubiquitinating enzymes (DUBs; 33). With reference to C. elegans, Ub, E1 and E2 were relatively conserved in sequence and structure, and E3s and DUBs were divergent, likely reflecti..

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University of Melbourne Researchers

Guangxu Ma Author

Tao Wang Author

Andreas Hofmann Author

Jiangning Song Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by grants from the Australian Research Council (ARC), namely LP180101085 (RBG), LP180101334 (NDY) and LP190101209 (RBG), and industry partners including Yourgene Health Singapore and PhylumTech (Argentina). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Ross S. Hall provided informatic support. YTZ was supported by a Melbourne Research Scholarship and the Rowden White Scholarship (Australia). Figures were created with BioRender.com. This research was undertaken using the LIEF HPC-GPGPU Facility, hosted at the University of Melbourne, Australia, established with the assistance of ARC grant LE170100200.